하이드록시아파타이트 코팅된 타이타늄의 플라즈마 처리가 조골모세포의 부착 및 분화에 미치는 효과
Effects of plasma surface modification to HA-coated titanium on preosteoblast adhesion and differentiation
이효진, 손준식, 권태엽, 김교한,
소속 상세정보
이효진 ( Lee Hyo-Jin ) - 경북대학교 치의학전문대학원 치과생체재료학교실
손준식 ( Son Jun-Sik ) - (재)한국섬유소재연구소
권태엽 ( Kwon Tae-Yub ) - 경북대학교 치의학전문대학원 치과생체재료학교실
김교한 ( Kim Kho-Han ) - 경북대학교 치의학전문대학원 치과생체재료학교실
KMID : 0362220130400030241
Abstract
Plasma technique has been proposed as a tool to produce a hydrophilic surface to hydroxyapatite (HA)-coated titanium, which is used as dental implant. The objective of this study was to evaluate the effect of plasma treated HA coated titanium on preosteoblast adhesion, proliferation and differentiation. The contact angle of plasma treated HA-coated titanium was lower than that of HA-coated titanium. Cells on HA-coated titanium and plasma treated HA-coated titanium spreaded and proliferated preosteoblast equally. But the MC3T3-E1 preosteoblast cells cultured on plasma treated HA-coated titanium enhanced the ALP activity and the expression of osteocalcin and osteopontin gene. The result demonstrated that atmospheric plasma decreased the contact angle of HA-coated titanium surface and promoted the differentiation of the MC3T3-E1 osteoblast cell by enhancing ALP activity, osteocalcin and osteopontin gene expression.
키워드
Plasma; HA-coated Titanium; Contact angle; Preosteoblast; Adhesion; Differentiation
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